An embodiment of the invention discloses a power amplification device and method and a method for acquiring a power adjusting coefficient. The power amplification device according to one embodiment of the invention includes: a power control module configured to perform power adjusting on an input signal; a power amplification module configured to perform power amplification on the signal subjected to the power adjusting by the power control module; and a pre-distortion module configured to compensate for nonlinear characteristic of the power amplification module; wherein, said power control module is coupled between said pre-distortion module and said power amplification module in series; alternatively, said pre-distortion module is coupled between said power control module and said power amplification module in series. With the embodiment of the invention, a transmitter can be provided with a spectrum including a low side lobe even upon startup.