A versatile personal emergency, especially medical emergency, communication system includes a user-carried portable communication unit having a single button, which when depressed by the user, wirelessly sends a call request signal to a base unit. The base unit initiates a telephone call through a dial-up network to an emergency response center and places an operator at the emergency center in wireless voice communication with the portable unit when the call is connected. The telephone number of the emergency responder to be called is stored in the system. A program is used to set up the system to a selected one of a central monitoring station and a 911 operator. Voice messages are stored in the system and are used to advise the user of the status of the call, and to provide the user with verbal confirmation that functional systems of the base unit are operating properly. The units are programmable selectively by phone, voice or computer.