Implementations and techniques for hybrid 2-D ECG data compression based on wavelet transforms are generally disclosed. In accordance with some implementations, a method for compressing electrocardiogram (ECG) data may include receiving a one-dimensional (1-D) ECG signal, generating a two-dimensional (2-D) ECG data array from the 1-D ECG signal, wavelet transforming the 2-D ECG data array to generate wavelet coefficients including a low frequency subband, a first intermediate frequency subband, a second intermediate frequency subband, and a high-frequency subband, and encoding the wavelet coefficients to generate compressed ECG data. Encoding the wavelet coefficients may include subjecting the low frequency subband, the first intermediate frequency subband, the second intermediate frequency subband, and the high frequency subband to different encoding schemes.