The present invention extends to methods, systems, and computer program products for optimizing access to federation infrastructure-based resources. Various different layers within a federation infrastructure can signal location change events indicating the hosting location and/or access location for a resource is to be optimized. In response to a location change event, redirection information for accessing the resource is updated within the federation infrastructure. The redirection information is used to redirect resource access requests to appropriately optimized locations within the federation infrastructure. Redirecting resource access requests reduces communication within the federation infrastructure.