Systems and methods for monitoring the performance associated with fulfilling resource requests and determining optimizations for improving such performance are provided. A processing device obtains and processes performance metric information associated with processing a request corresponding to a set of resources. The processing device uses the processed performance metric information to determine a resource configuration to be associated with the set of resources. In making such a determination, the processing device can assess performance metric information collected and associated with subsequent requests corresponding to the content associated with the set of resources and using each of a variety of alternative resource configurations. The processing device may also consider a number of factors. Aspects of systems and methods for generating recommendations to use a particular resource configuration to process a subsequent request corresponding to the content associated with the set of resources are also provided.