A system and method is disclosed for authenticating a removable data storage device (RDSD) by implementing a removable trusted information module (TIM) comprising a non-volatile storage medium operable to securely store passwords, digital keys, digital certificates and other security credentials (“security credentials”). An RDSD enclosure comprising a disk storage drive, one or more interfaces, one or more connectors, and a TIM is implemented to be connected, disconnected and reconnected to a plurality of predetermined information handling systems. The RDSD is authenticated by the TIM initiating comparison and cryptographic operations between its contents and the contents of authentication files comprising the RDSD. Once the RDSD has been authenticated, the TIM performs similar operations to authorize access and usage of its contents by the information handling system. Other cryptographic operations are performed to determine whether the integrity of data files has been compromised. Removal of the TIM prevents an information handling system from accessing the contents of the RDSD.