Stabilization systems and methods for various procedures (e.g., tissue ablation procedures) are disclosed. An exemplary stabilization system for use in a medical procedure may include a housing structure having a base portion, the housing structure insertable into a patient's body. The system may also include a securement element on the base portion of the housing structure. The system may also include a deployment mechanism in the housing structure and operably associated with the base portion. The deployment mechanism is operable to extend the base portion so that the at least one securement element engages a tissue in the patient's body after the housing structure is positioned adjacent a target area inside a patient's body. Embodiments of the securement element may include a membrane, a chamber, a frictional surface, at least one needle, peg, gasket, adhesive, and/or a collar.