A ligation apparatus includes a clip having a clip claw member advanced and retreated relative to a pressing member to be opened and closed, a sheath configured to accommodate the clip such that the clip claw member is not exposed to the outside, an advance and retreat restricting mechanism restricting advance and retreat of the pressing member relative to the sheath at a distal end portion of the sheath allowing advance and retreat of the clip claw member relative to the pressing member according to advance and retreat of the operation wire relative to the sheath so as to allow the clip ligaturing living tissue, and a releasing mechanism releasing at least a portion of the clip so that the clip ligatures the living tissue.