Invention Grant
US08551447B2 Bifunctional compound with monosaccharide and N2S2 ligand, and preparation and use thereof
有权
双官能化合物与单糖和N2S2配体，及其制备和应用
- Patent Title: Bifunctional compound with monosaccharide and N2S2 ligand, and preparation and use thereof
- Patent Title (中): 双官能化合物与单糖和N2S2配体，及其制备和应用
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Application No.: US13087664Application Date: 2011-04-15
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Publication No.: US08551447B2Publication Date: 2013-10-08
- Inventor: Show-Wen Liu , Cheng-Hsien Lin , Yu Chang , Cheng-Fang Hsu , Tsyh-Lang Lin
- Applicant: Show-Wen Liu , Cheng-Hsien Lin , Yu Chang , Cheng-Fang Hsu , Tsyh-Lang Lin
- Applicant Address: TW Taoyuan County
- Assignee: Institute of Nuclear Energy Research Atomic Energy Council, Executive Yuan
- Current Assignee: Institute of Nuclear Energy Research Atomic Energy Council, Executive Yuan
- Current Assignee Address: TW Taoyuan County
- Agency: WPAT, PC
- Agent Justin King
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
A bifunctional compound with a monosaccharide and a N2S2 ligand, and more particularly, a bifunctional compound with a N2S2 ligand and aminohexylacetyl galactosamine (ah-GalNAc4) is provided. A method for preparing the bifunctional compound with a monosaccharide and a N2S2 ligand is also provided, including activating a carboxyl group in an organic ligand, reacting the activated carboxyl group with a galactopyranoside through amidation, and then hydrolyzing. The bifunctional compound of the present invention is widely useful in nuclear medicine for preparation of liver imaging agents for assisting in correct diagnosis of diseases.
Public/Granted literature
- US20120009669A1 BIFUNCTIONAL COMPOUND WITH MONOSACCHARIDE AND N2S2 LIGAND, AND PREPARATION AND USE THEREOF Public/Granted day:2012-01-12
Information query
IPC分类:
