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Invention Grant
US08551491B2 Processes for the preparation of a batch of an active pharmaceutical ingredient, a container comprising cryogranules of an allergen product, and a cryogranule of an allergen product 有权
用于制备一批活性药物成分的方法，包含变应原产物的低温颗粒的容器和变应原产物的低温颗粒

Processes for the preparation of a batch of an active pharmaceutical ingredient, a container comprising cryogranules of an allergen product, and a cryogranule of an allergen product
Abstract:
The present invention relates to processes for the preparation of a batch of an active pharmaceutical ingredient, e.g. an allergen product. The invention also relates to a container comprising cryogranules of a liquid composition of an allergen product, and to a cryogranule of an allergen product. The processes feature formation of cryogranules using a container having therein a cryogenic medium (e.g. liquid nitrogen) and storage of the cryogranules in the same container. The cryogranules obtained can be stored and handled without prior freeze-drying.
Abstract(Chinese):

本发明涉及制备一批活性药物成分的方法，例如， 过敏原产品。 本发明还涉及包含变应原产物的液体组合物的低温颗粒和变应原产物的低温颗粒的容器。 该方法的特征是使用其中具有低温介质（例如液氮）的容器并将低温颗粒储存在同一容器中来形成低温颗粒。 获得的低温颗粒可以储存和处理，而无需预先冷冻干燥。

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