Invention Grant
US08551779B2 DDR1-mediated cell purification of pancreatic endocrine cells through their progenitors 失效
DDR1介导的胰腺内分泌细胞通过其祖细胞纯化

  • Patent Title: DDR1-mediated cell purification of pancreatic endocrine cells through their progenitors
  • Patent Title (中): DDR1介导的胰腺内分泌细胞通过其祖细胞纯化
  • Application No.: US12810960
    Application Date: 2008-12-19
  • Publication No.: US08551779B2
    Publication Date: 2013-10-08
  • Inventor: Jacob HaldOle Dragsbæk MadsenPalle Serup
  • Applicant: Jacob HaldOle Dragsbæk MadsenPalle Serup
  • Applicant Address: DK Bagsvaerd
  • Assignee: Novo Nordisk A/S
  • Current Assignee: Novo Nordisk A/S
  • Current Assignee Address: DK Bagsvaerd
  • Agent Jianjie Hu
  • Priority: EP07124132 20071228
  • International Application: PCT/EP2008/068061 WO 20081219
  • International Announcement: WO2009/083502 WO 20090709
  • Main IPC: C12N5/08
  • IPC: C12N5/08
DDR1-mediated cell purification of pancreatic endocrine cells through their progenitors
Abstract:
The invention relates to a method of identifying, obtaining and/or quantifying a culture of pancreatic cells selected from the group consisting of ductal/endocrine progenitor cells, endocrine progenitor cells, early endocrine cells, and fully differentiated endocrine cells. Also contemplated is a method of expanding the numbers of such cells as well as sorting such cells. The invention further relates to a selective cell surface marker, DDR1, that permits the selection of a unique subset of cells with pancreatic endocrine progenitor phenotype. Furthermore, the invention relates to isolated cells selected from such cells and compositions thereof.
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