Invention Grant
US08551779B2 DDR1-mediated cell purification of pancreatic endocrine cells through their progenitors
失效
DDR1介导的胰腺内分泌细胞通过其祖细胞纯化
- Patent Title: DDR1-mediated cell purification of pancreatic endocrine cells through their progenitors
- Patent Title (中): DDR1介导的胰腺内分泌细胞通过其祖细胞纯化
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Application No.: US12810960Application Date: 2008-12-19
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Publication No.: US08551779B2Publication Date: 2013-10-08
- Inventor: Jacob Hald , Ole Dragsbæk Madsen , Palle Serup
- Applicant: Jacob Hald , Ole Dragsbæk Madsen , Palle Serup
- Applicant Address: DK Bagsvaerd
- Assignee: Novo Nordisk A/S
- Current Assignee: Novo Nordisk A/S
- Current Assignee Address: DK Bagsvaerd
- Agent Jianjie Hu
- Priority: EP07124132 20071228
- International Application: PCT/EP2008/068061 WO 20081219
- International Announcement: WO2009/083502 WO 20090709
- Main IPC: C12N5/08
- IPC: C12N5/08

Abstract:
The invention relates to a method of identifying, obtaining and/or quantifying a culture of pancreatic cells selected from the group consisting of ductal/endocrine progenitor cells, endocrine progenitor cells, early endocrine cells, and fully differentiated endocrine cells. Also contemplated is a method of expanding the numbers of such cells as well as sorting such cells. The invention further relates to a selective cell surface marker, DDR1, that permits the selection of a unique subset of cells with pancreatic endocrine progenitor phenotype. Furthermore, the invention relates to isolated cells selected from such cells and compositions thereof.
Public/Granted literature
- US20110014160A1 DDR1-Mediated Cell Purification of Pancreatic Endocrine Cells Through Their Progenitors Public/Granted day:2011-01-20
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