Invention Grant
US08551789B2 Frizzled-binding agents and their use in screening for WNT inhibitors
有权
卷曲结合剂及其在筛选WNT抑制剂中的应用
- Patent Title: Frizzled-binding agents and their use in screening for WNT inhibitors
- Patent Title (中): 卷曲结合剂及其在筛选WNT抑制剂中的应用
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Application No.: US13078728Application Date: 2011-04-01
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Publication No.: US08551789B2Publication Date: 2013-10-08
- Inventor: Austin L. Gurney
- Applicant: Austin L. Gurney
- Applicant Address: US CA Redwood City
- Assignee: OncoMed Pharmaceuticals
- Current Assignee: OncoMed Pharmaceuticals
- Current Assignee Address: US CA Redwood City
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: G01N33/566
- IPC: G01N33/566 ; C07K14/435 ; C07K7/06 ; C07K7/64
Abstract:
Novel anti-cancer agents, including, but not limited to, antibodies and other polypeptides, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided. Screening methods are also provided.
Public/Granted literature
- US20120027778A1 Frizzled-Binding Agents and Uses Thereof Public/Granted day:2012-02-02
Information query
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