Invention Grant
- Patent Title: Dimeric Smac mimetics
- Patent Title (中): 二聚Smac模拟物
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Application No.: US12914840Application Date: 2010-10-28
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Publication No.: US08551955B2Publication Date: 2013-10-08
- Inventor: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
- Applicant: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
- Applicant Address: US TX Dallas
- Assignee: Joyant Pharmaceuticals, Inc.
- Current Assignee: Joyant Pharmaceuticals, Inc.
- Current Assignee Address: US TX Dallas
- Agent Richard Aron Osman
- Main IPC: A61K38/06
- IPC: A61K38/06 ; A61K38/08 ; C07C45/87
Abstract:
The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
Public/Granted literature
- US20110195043A1 Dimeric Smac Mimetics Public/Granted day:2011-08-11
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