Invention Grant
US08551991B2 1,2,3,4-tetrahydroquinoxaline derivative having glucocorticoid receptor binding activity
有权
具有糖皮质激素受体结合活性的1,2,3,4-四氢喹喔啉衍生物
- Patent Title: 1,2,3,4-tetrahydroquinoxaline derivative having glucocorticoid receptor binding activity
- Patent Title (中): 具有糖皮质激素受体结合活性的1,2,3,4-四氢喹喔啉衍生物
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Application No.: US12225010Application Date: 2007-03-14
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Publication No.: US08551991B2Publication Date: 2013-10-08
- Inventor: Mamoru Matsuda , Toshiyuki Mori , Kenji Kawashima , Minoru Yamamoto , Masatomo Kato , Miwa Takai , Masato Nagatsuka , Sachiko Kobayashi
- Applicant: Mamoru Matsuda , Toshiyuki Mori , Kenji Kawashima , Minoru Yamamoto , Masatomo Kato , Miwa Takai , Masato Nagatsuka , Sachiko Kobayashi
- Applicant Address: JP Osaka
- Assignee: Santen Pharmaceutical Co., Ltd.
- Current Assignee: Santen Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Holtz Holtz Goodman & Chick PC
- Priority: JP2006-069739 20060314; JP2006-255039 20060822
- International Application: PCT/JP2007/055122 WO 20070314
- International Announcement: WO2007/105766 WO 20070920
- Main IPC: A61K31/535
- IPC: A61K31/535 ; A61K31/44 ; A01N43/40

Abstract:
An object of the present invention is to synthesize a novel 1,2,3,4-tetrahydroquinoxaline derivative represented by formula (1) and to find a pharmacological action of the derivative. In the formula, the R1 represents a halogen, an alkyl, cycloalkyl, aryl or heterocyclic group, or the like; p represents 0 to 5; R2 represents a halogen, an alkyl, hydroxyl or alkoxy group, or the like; q represents 0 to 2; R3 represents hydrogen, an alkyl, alkenyl, alkylcarbonyl or arylcarbonyl group, or the like; R4 and R5 independently represent hydrogen, a halogen, an alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclic group, or the like; R6 represents hydrogen, an alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclic group, or the like; A represents an alkylene; R7 represents OR8, NR8R9, SR8, S(O)R8, S(O)2R8; and X represents O or S.
Public/Granted literature
- US20090111807A1 Novel 1,2,3,4-Tetrahydroquinoxaline Derivative Having Glucocorticoid Receptor Binding Activity Public/Granted day:2009-04-30
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