Invention Grant
- Patent Title: TNF-α antagonists containing IGFBP5
- Patent Title (中): 含有IGFBP5的TNF-α拮抗剂
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Application No.: US13142700Application Date: 2009-06-30
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Publication No.: US08552148B2Publication Date: 2013-10-08
- Inventor: Je-Ho Lee , Jae-Ryoung Hwang , Jae-Ho Huh
- Applicant: Je-Ho Lee , Jae-Ryoung Hwang , Jae-Ho Huh
- Applicant Address: KR Gyeonggi-do
- Assignee: Sungkyunkwan University Foundation For Corporate Collaboration
- Current Assignee: Sungkyunkwan University Foundation For Corporate Collaboration
- Current Assignee Address: KR Gyeonggi-do
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Priority: KR10-2008-0138164 20081231
- International Application: PCT/KR2009/003570 WO 20090630
- International Announcement: WO2010/076932 WO 20100708
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K51/00 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K2/00 ; C07K4/00 ; C07K14/00 ; C07K17/00
Abstract:
The present invention relates to: TNF-α antagonists containing IGFBP5 protein, variants thereof, or fragments thereof; and the use of the TNF-α antagonists. More specifically, the present invention relates to: a polynucleotide encoding the protein, variants thereof, or fragments thereof; a vector containing the polynucleotide; a transformant containing the vector; and a method for screening a therapeutic agent for TNF-α overexpression-related diseases by checking whether the mutual reaction thereof is facilitated after treating with candidates to the cell expressing the IGFBP5 protein, variants thereof, or fragments thereof, and the TNFR1.
Public/Granted literature
- US20120046217A1 TNF-alpha Antagonists Containing IGFBP5 Public/Granted day:2012-02-23
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