Invention Grant
- Patent Title: Polypeptides and use thereof
- Patent Title (中): 多肽及其用途
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Application No.: US13142835Application Date: 2009-11-30
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Publication No.: US08552149B2Publication Date: 2013-10-08
- Inventor: Christina Furebring , Anna Rosén , Karin Haraldsson , Erika Gustafsson , Björn Ulrik Walse
- Applicant: Christina Furebring , Anna Rosén , Karin Haraldsson , Erika Gustafsson , Björn Ulrik Walse
- Applicant Address: SE Lund
- Assignee: Alligator Bioscience AB
- Current Assignee: Alligator Bioscience AB
- Current Assignee Address: SE Lund
- Agency: Morrison & Foerster LLP
- Priority: GB0905790.2 20090403
- International Application: PCT/GB2009/002782 WO 20091130
- International Announcement: WO2010/079314 WO 20100715
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A61P9/00 ; C07K14/00
Abstract:
The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of Staphylococcus aureus (‘CHIPS’), the polypeptide comprising or consisting of the amino acid sequence of SEQ ID NO: 2, or a fragment or variant thereof having a biological activity of CHIPS, wherein the fragment or variant retains amino acid substitutions K40E, D42V, N77H, K100R, K105R, N111 K and/or G112A relative to the wildtype CHIPS protein of SEQ ID NO:1. In one embodiment, polypeptide consists of the amino acid sequence of SEQ ID NO: 2. Related aspects of the invention provide pharmaceutical compositions comprising a polypeptide of the invention, together with methods or making and using the same.
Public/Granted literature
- US20120071394A1 NOVEL POLYPEPTIDES AND USE THEREOF Public/Granted day:2012-03-22
Information query
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