Invention Grant
US08552181B2 Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
有权
取代的羟乙基胺化合物作为β-分泌酶调节剂和使用方法
- Patent Title: Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
- Patent Title (中): 取代的羟乙基胺化合物作为β-分泌酶调节剂和使用方法
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Application No.: US13410201Application Date: 2012-03-01
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Publication No.: US08552181B2Publication Date: 2013-10-08
- Inventor: Wenge Zhong , Stephen Hitchcock , Vinod F. Patel , Michael Croghan , Thomas Dineen , Scott Harried , Daniel Horne , Ted Judd , Matthew Walker , Charles Kreiman , Patricia Lopez , Holger Monenschein , Thomas Nguyen , Matthew Weiss , Qiufen Xue , Bryant Yang , Russell Graceffa
- Applicant: Wenge Zhong , Stephen Hitchcock , Vinod F. Patel , Michael Croghan , Thomas Dineen , Scott Harried , Daniel Horne , Ted Judd , Matthew Walker , Charles Kreiman , Patricia Lopez , Holger Monenschein , Thomas Nguyen , Matthew Weiss , Qiufen Xue , Bryant Yang , Russell Graceffa
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent G. Prabhakar Reddy
- Main IPC: C07D471/10
- IPC: C07D471/10 ; C07D491/107 ; C07D495/10
Abstract:
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase activity and for the treatment of diseases, including Alzheimer's disease (AD) and related CNS conditions, mediated thereby. In one embodiment, the compounds have a general Formula I or Formula II wherein R1a-1c, B, R3-5 and W of Formula I, and R1a-1c, R2-5, A1-4, W, X, Z, m and n of Formula II are defined herein. The invention further provides compounds of Formula III and IV and sub-Formulas II-A-II-D and III-A-III-D. The compounds may be used in pharmaceutical compositions for treating, prophylactically or therapeutically, disorders related to the activity of beta-secretase protein, including without limitation, AD, cognitive deficits and impairment, schizophrenia and other similar central nervous system conditions.
Public/Granted literature
- US20120220583A1 SUBSTITUTED HYDROXYETHYL AMINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE Public/Granted day:2012-08-30
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