Invention Grant
US08552191B2 Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
有权
用于合成8 - [{1-（3,5-双 - （三氟甲基）苯基） - 乙氧基} - 甲基] -8-苯基-1,7-二氮杂 - 螺[4.5]癸-2-醇的方法和中间体 一种化合物
![Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds](/docs/US/2013-10-08/US08552191B2/abs.jpg.600x600.jpg)
- Patent Title: Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
- Patent Title (中): 用于合成8 - [{1-（3,5-双 - （三氟甲基）苯基） - 乙氧基} - 甲基] -8-苯基-1,7-二氮杂 - 螺[4.5]癸-2-醇的方法和中间体 一种化合物
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Application No.: US12531859Application Date: 2008-03-20
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Publication No.: US08552191B2Publication Date: 2013-10-08
- Inventor: Ingrid Mergelsberg , Dominik Hermann Scherer , Monika Erika Huttenloch , Hon-Chung Tsui , Sunil Paliwal , Neng-Yang Shih
- Applicant: Ingrid Mergelsberg , Dominik Hermann Scherer , Monika Erika Huttenloch , Hon-Chung Tsui , Sunil Paliwal , Neng-Yang Shih
- Applicant Address: US FL Miami
- Assignee: Opko Health, Inc.
- Current Assignee: Opko Health, Inc.
- Current Assignee Address: US FL Miami
- Agency: Choate Hall & Stewart LLP
- Agent Brenda Herschbach Jarrell; Kristen C. Buteau
- International Application: PCT/US2008/003640 WO 20080320
- International Announcement: WO2008/118328 WO 20081002
- Main IPC: C07D221/20
- IPC: C07D221/20
![Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds](/abs-image/US/2013/10/08/US08552191B2/abs.jpg.150x150.jpg)
Abstract:
This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations.
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