Invention Grant
- Patent Title: Apoptosis signal-regulating kinase inhibitors
- Patent Title (中): 细胞凋亡信号调节激酶抑制剂
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Application No.: US13615259Application Date: 2012-09-13
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Publication No.: US08552196B2Publication Date: 2013-10-08
- Inventor: Britton Corkey , Michael Graupe , Keith Koch , Lawrence S. Melvin, Jr. , Gregory Notte
- Applicant: Britton Corkey , Michael Graupe , Keith Koch , Lawrence S. Melvin, Jr. , Gregory Notte
- Applicant Address: US CA Foster City
- Assignee: Gilead Sciences, Inc.
- Current Assignee: Gilead Sciences, Inc.
- Current Assignee Address: US CA Foster City
- Agent Francis O. Ginah; J. Elin Hartrum
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; A61K31/444 ; A61K31/496 ; A61K31/506 ; A61K31/5377 ; A61P1/16 ; A61P25/28 ; A61P29/00 ; A61P37/06 ; A61P13/12 ; A61P9/00 ; A61P3/10 ; A61P11/00
Abstract:
The present invention relates to compounds of Formula (I): wherein X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are defined above. The compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
Public/Granted literature
- US20130035339A1 APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS Public/Granted day:2013-02-07
Information query
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