Methods and systems to adjust a phase difference between signals, such as to perform quadrature phase correction. First and second signals are digitally compared, such as with exclusive OR circuitry, to provide a comparison signal having a duty cycle representative of a phase difference between the signals. A phase delay of one or both of the first and second signals is adjusted until the duty cycle of the comparison signal corresponds to a desired phase difference. In a clock and data recovery system, the signals may correspond to a zero degree phase of a first phase interpolator and a ninety degree phase of a second phase interpolator, and digital codes to the first and second phase interpolators may be adjusted to provide a fifty percent duty cycle in the comparison signal.