A system and method for estimating a location of a wireless device in a wireless communication system having a plurality of nodes and a plurality of location measurement units (“LMUs”). A set of signal samples from a first wireless device and a second wireless device may be collected by one or more LMUs in a search window. A first time of arrival (“TOA”) is determined, and a second search window is estimated as a function of the first TOA. A second TOA may be determined within the second search window at a second node or one of the LMUs from the set of signal samples. A range estimate of the wireless device may then be determined, and an estimated location of the wireless device may be determined as a function of the first uplink TOA, the second uplink TOA, or the range estimate and second TOA.