A method and system of controlling access to a system in a medical environment is provided. The method includes calculating a signature value for at least one file usable with the medical system, transferring the calculated signature value to a signature file, and providing at least one signature value in the signature file and at least one associated file to a file system configured to be received by the medical system. At least one signature value and at least one associated file are inspected by the medical system to verify the associated file is a known medical software application asset. The medical system comprises an input/output data port configured to receive the external memory storage device, and an operating system capable of reading medical system data from and writing medical system data to the memory storage device.