Invention Grant
- Patent Title: EphA2 T cell epitopes and uses therefor
- Patent Title (中): EphA2 T细胞表位及其用途
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Application No.: US13355343Application Date: 2012-01-20
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Publication No.: US08574584B2Publication Date: 2013-11-05
- Inventor: Walter J. Storkus , Michael S. Klnch
- Applicant: Walter J. Storkus , Michael S. Klnch
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh —of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh —of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Baker Botts, L.L.P.
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K38/00 ; C12N15/09
Abstract:
EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell epitopes, and conservative derivatives thereof. The EphA2 T-cell epitopes are useful in an assay, such as an ELISPOT assay, that may be used to determine and/or quantify a patient's immune responsiveness to EphA2. The epitopes also are useful in methods of modulating a patient's immune reactivity to EphA2, which has substantial utility as a treatment for cancers that overexpress EphA2, such as renal cell carcinoma (RCC). The EphA2 epitopes also can be used to vaccinate a patient against EphA2, by in vivo or ex vivo methods.
Public/Granted literature
- US20120201840A1 EphA2 T-Cell Epitopes and Uses Therefor Public/Granted day:2012-08-09
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