Invention Grant
US08574592B2 Modified influenza virus for monitoring and improving vaccine efficiency
有权
用于监测和改善疫苗效率的改良流感病毒
- Patent Title: Modified influenza virus for monitoring and improving vaccine efficiency
- Patent Title (中): 用于监测和改善疫苗效率的改良流感病毒
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Application No.: US13614835Application Date: 2012-09-13
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Publication No.: US08574592B2Publication Date: 2013-11-05
- Inventor: Erich Hoffmann , Aleksandr S. Lipatov , Richard J. Webby , Elena A. Govorkova , Robert G. Webster
- Applicant: Erich Hoffmann , Aleksandr S. Lipatov , Richard J. Webby , Elena A. Govorkova , Robert G. Webster
- Applicant Address: US TN Memphis
- Assignee: St. Jude Children's Research Hospital
- Current Assignee: St. Jude Children's Research Hospital
- Current Assignee Address: US TN Memphis
- Agency: Troutman Sanders LLP
- Main IPC: A61K39/145
- IPC: A61K39/145 ; A61K39/12 ; A61K39/00 ; A01N63/00 ; C12Q1/70 ; C12P21/06 ; C07K14/00
Abstract:
The immunogenicity of the influenza virus hemagglutinin (HA) molecule may be increased by substitutions of amino acids in the HA sequence. The substitution of specific HA residues, such as asparagine at position 223 of H5 HA, increase the sensitivity of the hemagglutinin inhibition (HI) assay by altering receptor specificity and/or antibody-antigen binding. HA molecules containing such substitutions will be useful in the development of diagnostic reference viruses and improved influenza vaccines.
Public/Granted literature
- US20130017216A1 Modified Influenza Virus For Monitoring And Improving Vaccine Efficiency Public/Granted day:2013-01-17
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