A system comprising a plurality of implantable pellets, wherein one such implantable pellet delivers localized, controlled and sustained release of a predetermined quantity of one or more pain relief agents, in optional combination with one or more anti-inflammatory agents, one or more polymeric excipients, and/or one or more surfactants. An anesthetic/analgesic pellet is used in combination with one or more pharmaceutical pellets as part of a single procedure to provide desired a pharmaceutical to the animal while simultaneously alleviating pain and, optionally, inflammation at the injection site.