The present invention relates to a membrane-electrode assembly for a fuel cell and a fuel cell system comprising the same. The membrane-electrode assembly includes an anode and a cathode facing each other and a polymer electrolyte membrane positioned therebetween. The polymer electrolyte membrane adheres to the anode through a binder disposed between the polymer electrolyte membrane and the anode, and adheres to the cathode through a binder disposed between the polymer electrolyte membrane and the cathode. The binder and the polymer electrolyte membrane can include a cation exchange resin and an inorganic additive.