Invention Grant
US08574837B2 System for screening agonists/antagonists of cellular signaling pathways
失效
用于筛选细胞信号通路的激动剂/拮抗剂的系统
- Patent Title: System for screening agonists/antagonists of cellular signaling pathways
- Patent Title (中): 用于筛选细胞信号通路的激动剂/拮抗剂的系统
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Application No.: US13142438Application Date: 2009-12-29
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Publication No.: US08574837B2Publication Date: 2013-11-05
- Inventor: Yu Wang , Andrew P. McMahon
- Applicant: Yu Wang , Andrew P. McMahon
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Nixon Peabody LLP
- Agent David S. Resnick
- International Application: PCT/US2009/069640 WO 20091229
- International Announcement: WO2010/078290 WO 20100708
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The present invention identifies a method for investigating the response of a cell membrane-associated protein in a living cell to a drug by labeling the protein with a visual marker, and also selectively labeling the membrane portion of the protein with another visual marker, such that upon exposure of the cell to a stimulus, the translocation of the cell membrane-associated protein may be observed directly.
Public/Granted literature
- US20110319286A1 SYSTEM FOR SCREENING AGONISTS/ANTAGONISTS OF CELLULAR SIGNALING PATHWAYS Public/Granted day:2011-12-29
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