Invention Grant
US08574865B2 Methods and assays for identifying compounds that modulate protein-protein interactions
有权
用于鉴定调节蛋白质 - 蛋白质相互作用的化合物的方法和测定法
- Patent Title: Methods and assays for identifying compounds that modulate protein-protein interactions
- Patent Title (中): 用于鉴定调节蛋白质 - 蛋白质相互作用的化合物的方法和测定法
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Application No.: US12676284Application Date: 2008-08-28
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Publication No.: US08574865B2Publication Date: 2013-11-05
- Inventor: Paul Steven Wright , Paul Weissensee , Haifeng Eishingdrelo , Jidong Cai
- Applicant: Paul Steven Wright , Paul Weissensee , Haifeng Eishingdrelo , Jidong Cai
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agency: Lathrop & Gage LLP
- Agent James H. Velema, Esq.
- International Application: PCT/US2008/074543 WO 20080828
- International Announcement: WO2009/032716 WO 20090312
- Main IPC: C12Q1/37
- IPC: C12Q1/37
Abstract:
Methods and assays for identifying a compound that modulates a protein-protein interaction between a first and a second protein. The methods and assays require a protease that is attached to the second protein and a split and rearranged reporter activating protein that is attached to the first protein, wherein the reporter activating protein comprises a cleavage site for the protease that is interposed between two portions of the reporter activating protein and wherein the two portions of the reporter activating protein are in a rearranged order.
Public/Granted literature
- US20100311096A1 IDENTIFYING MOLECULES MODULATING PROTEIN-PROTEIN INTERACTIONS USING PROTEASE ACTIVATED REPORTERS Public/Granted day:2010-12-09
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