Invention Grant
- Patent Title: Treatment of cancers with A-8R peptide
- Patent Title (中): 用A-8R肽治疗癌症
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Application No.: US13375307Application Date: 2010-05-28
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Publication No.: US08575087B2Publication Date: 2013-11-05
- Inventor: Lirim Shemshedini , Shao-Yong Chen , Changmeng Cai , Chen-Lin Hsieh
- Applicant: Lirim Shemshedini , Shao-Yong Chen , Changmeng Cai , Chen-Lin Hsieh
- Applicant Address: US OH Toledo
- Assignee: The University of Toledo
- Current Assignee: The University of Toledo
- Current Assignee Address: US OH Toledo
- Agency: MacMillan, Sobanski & Todd, LLC
- International Application: PCT/US2010/036563 WO 20100528
- International Announcement: WO2010/141349 WO 20101209
- Main IPC: A61K38/04
- IPC: A61K38/04

Abstract:
The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.
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