Invention Grant
US08575121B2 Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
有权
p53异构体在再生医学，衰老和癌症中的治疗应用
- Patent Title: Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
- Patent Title (中): p53异构体在再生医学，衰老和癌症中的治疗应用
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Application No.: US12742250Application Date: 2008-10-21
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Publication No.: US08575121B2Publication Date: 2013-11-05
- Inventor: Curtis C. Harris , Kaori Fujita , Izumi Horikawa , Borivoj Vojtesek , Jean-Christophe Bourdon , David P. Lane
- Applicant: Curtis C. Harris , Kaori Fujita , Izumi Horikawa , Borivoj Vojtesek , Jean-Christophe Bourdon , David P. Lane
- Applicant Address: US DC Washington GB Dundee, Scotland CZ Brno
- Assignee: The United States of America as represented by the Secetary of the Department of Health and Human Services,The University of Dundee,Masaryk Memorial Cancer Institute
- Current Assignee: The United States of America as represented by the Secetary of the Department of Health and Human Services,The University of Dundee,Masaryk Memorial Cancer Institute
- Current Assignee Address: US DC Washington GB Dundee, Scotland CZ Brno
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/US2008/080648 WO 20081021
- International Announcement: WO2009/064590 WO 20090522
- Main IPC: C12N15/11
- IPC: C12N15/11
Abstract:
The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.
Public/Granted literature
- US20110243968A1 THERAPEUTIC APPLICATIONS OF P53 ISOFORMS IN REGENERATIVE MEDICINE, AGING AND CANCER Public/Granted day:2011-10-06
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