Invention Grant
US08575141B2 Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer
有权
类固醇衍生的环巴胺类似物及其在预防或治疗癌症中的应用
- Patent Title: Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer
- Patent Title (中): 类固醇衍生的环巴胺类似物及其在预防或治疗癌症中的应用
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Application No.: US12739991Application Date: 2008-10-30
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Publication No.: US08575141B2Publication Date: 2013-11-05
- Inventor: Nadia Dahmane , Jeffrey D. Winkler
- Applicant: Nadia Dahmane , Jeffrey D. Winkler
- Applicant Address: US PA Philadelphia US PA Philadelphia
- Assignee: The Wistar Institute,The Trustees of the University of Pennsylvania
- Current Assignee: The Wistar Institute,The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia US PA Philadelphia
- Agency: Licata & Tyrrell, P.C.
- International Application: PCT/US2008/081704 WO 20081030
- International Announcement: WO2009/058945 WO 20090507
- Main IPC: A61K31/58
- IPC: A61K31/58
Abstract:
The present invention relates to steroid-derived cyclopamine analogs and methods for using the same for inhibiting sonic hedgehog signaling and preventing or treating cancer. A method for synthesizing the analogs of the present invention from a steroid is also provided.
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