Invention Grant
- Patent Title: Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
- Patent Title (中): 11β-羟基类固醇脱氢酶的循环抑制剂1
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Application No.: US12670205Application Date: 2008-07-25
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Publication No.: US08575156B2Publication Date: 2013-11-05
- Inventor: David A. Claremon , Wei He , Gerard McGeehan , Suresh B. Singh , Colin M. Tice , Zhenrong Xu , Yuanjie Ye , Wei Zhao , Linghang Zhuang , Salvacion Cacatian , Katerina Leftheris
- Applicant: David A. Claremon , Wei He , Gerard McGeehan , Suresh B. Singh , Colin M. Tice , Zhenrong Xu , Yuanjie Ye , Wei Zhao , Linghang Zhuang , Salvacion Cacatian , Katerina Leftheris
- Applicant Address: US PA Fort Washington
- Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee Address: US PA Fort Washington
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Michael J. DeGrazia
- International Application: PCT/US2008/009017 WO 20080725
- International Announcement: WO2009/017664 WO 20090205
- Main IPC: C07D413/10
- IPC: C07D413/10 ; C07D413/04 ; C07D241/04 ; A61K31/675 ; A61K31/5377 ; A61K31/541

Abstract:
Disclosed are compounds represented by Formula (I): or pharmaceutically acceptable salts, enantiomers or diastereomers thereof. Also disclosed are pharmaceutical compositions comprising the compounds of Formula (I) or pharmaceutically acceptable salts, enantiomers or diastereomers thereof and methods of inhibiting 11β-HSD1 activity comprising the step of administering to a mammal in need of such treatment an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof. Values for the variables in Formula (I) are defined herein.
Public/Granted literature
- US20110015157A1 CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 Public/Granted day:2011-01-20
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