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US08575156B2 Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 失效
11β-羟基类固醇脱氢酶的循环抑制剂1

Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
Abstract:
Disclosed are compounds represented by Formula (I): or pharmaceutically acceptable salts, enantiomers or diastereomers thereof. Also disclosed are pharmaceutical compositions comprising the compounds of Formula (I) or pharmaceutically acceptable salts, enantiomers or diastereomers thereof and methods of inhibiting 11β-HSD1 activity comprising the step of administering to a mammal in need of such treatment an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof. Values for the variables in Formula (I) are defined herein.
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