Invention Grant
- Patent Title: Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
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Application No.: US13318271Application Date: 2010-04-30
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Publication No.: US08575157B2Publication Date: 2013-11-05
- Inventor: Martin Renz , Martin Schuehle , Zhenrong Xu
- Applicant: Martin Renz , Martin Schuehle , Zhenrong Xu
- Applicant Address: US PA Fort Washington DE
- Assignee: Vitae Pharmaceuticals, Inc.,Boehringer Ingelheim International, GmbH
- Current Assignee: Vitae Pharmaceuticals, Inc.,Boehringer Ingelheim International, GmbH
- Current Assignee Address: US PA Fort Washington DE
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Michael J. DeGrazia
- International Application: PCT/US2010/033157 WO 20100430
- International Announcement: WO2010/127237 WO 20101104
- Main IPC: C07D413/14
- IPC: C07D413/14 ; A61K31/535
Abstract:
This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, lo1, lo2, lo5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
Public/Granted literature
- US08680093B2 Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 Public/Granted day:2014-03-25
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