Invention Grant
- Patent Title: Spiro compounds having stearoyl-CoA desaturase action
- Patent Title (中): 具有硬脂酰-CoA去饱和酶作用的螺环化合物
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Application No.: US12449320Application Date: 2008-02-05
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Publication No.: US08575167B2Publication Date: 2013-11-05
- Inventor: Takahiko Taniguchi , Kenichi Miyata , Osamu Kubo
- Applicant: Takahiko Taniguchi , Kenichi Miyata , Osamu Kubo
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2007-027404 20070206; JP2007-139645 20070525
- International Application: PCT/JP2008/051849 WO 20080205
- International Announcement: WO2008/096746 WO 20080814
- Main IPC: A61K31/50
- IPC: A61K31/50 ; C07D401/00 ; A61P3/04 ; A61P3/06 ; A61P7/12 ; A61P9/12 ; A61P9/04 ; A61P9/00 ; A61P9/10

Abstract:
The present invention aims to provide a novel SCD inhibitor.The present invention relate to SCD inhibitor comprising A compound represented by the formula (I) wherein R is an optionally substituted cyclic group or an optionally substituted carbamoyl group, provided that R is not an optionally substituted 7-pyrido[2,3-d]pyrimidyl group; ring A is an optionally further substituted pyridazine ring; R1, R2, R3, R4, R11, R12, R13 and R14 are each independently a hydrogen atom or a substituent, or R1 and R11 in combination, R2 and R12 in combination, R3 and R13 in combination, or R4 and R14 in combination optionally form an oxo group, or R2 and R4 in combination optionally form a bond or an alkylene cross-linkage; m and n are each independently an integer of 0 to 2; ring B is an optionally substituted ring, provided that the two atoms constituting ring B, which are adjacent to the spiro carbon atom, are not oxygen atoms at the same time, or a salt thereof, or a prodrug thereof.
Public/Granted literature
- US20100069351A1 SPIRO COMPOUND AND USE THEREOF Public/Granted day:2010-03-18
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