Invention Grant
- Patent Title: Inhibitors of serine proteases
- Patent Title (中): 丝氨酸蛋白酶抑制剂
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Application No.: US12528952Application Date: 2008-02-20
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Publication No.: US08575208B2Publication Date: 2013-11-05
- Inventor: Luc Farmer , Randy Scott Bethiel , Dylan Jacobs , Robert B. Perni , John Maxwell , Kevin Cottrell , Summer Halas
- Applicant: Luc Farmer , Randy Scott Bethiel , Dylan Jacobs , Robert B. Perni , John Maxwell , Kevin Cottrell , Summer Halas
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Cambridge
- Agency: Honigman Miller Schwarz and Cohn
- Agent Kathryn D. Soulier; Jonathan P. O'Brien
- International Application: PCT/US2008/002395 WO 20080220
- International Announcement: WO2008/106058 WO 20080904
- Main IPC: A61K31/4025
- IPC: A61K31/4025 ; C07D207/08

Abstract:
The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention.
Public/Granted literature
- US20100272681A1 Inhibitors of Serine Proteases Public/Granted day:2010-10-28
Information query
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