Invention Grant
US08575210B2 Use of indole derivatives as NURR-1 activators for treating parkinson's disease
有权
使用吲哚衍生物作为NURR-1激活剂治疗帕金森病
- Patent Title: Use of indole derivatives as NURR-1 activators for treating parkinson's disease
- Patent Title (中): 使用吲哚衍生物作为NURR-1激活剂治疗帕金森病
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Application No.: US13003554Application Date: 2009-07-09
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Publication No.: US08575210B2Publication Date: 2013-11-05
- Inventor: Benaïssa Boubia , Johannes Bernard Van Vliet , Joseph Antonius Jacobus Den Hartog , Andrew McCreary , Mireille Tallandier , Petronella Johanna Maria Van Dongen , Olivia Poupardin-Olivier
- Applicant: Benaïssa Boubia , Johannes Bernard Van Vliet , Joseph Antonius Jacobus Den Hartog , Andrew McCreary , Mireille Tallandier , Petronella Johanna Maria Van Dongen , Olivia Poupardin-Olivier
- Applicant Address: FR Dijon
- Assignee: Laboratoires Fournier SA
- Current Assignee: Laboratoires Fournier SA
- Current Assignee Address: FR Dijon
- Agency: Crowell & Moring LLP
- Priority: FR0854712 20080710
- International Application: PCT/FR2009/051372 WO 20090709
- International Announcement: WO2010/004221 WO 20100114
- Main IPC: A61K31/405
- IPC: A61K31/405 ; C07D209/04

Abstract:
The present invention relates to a compound derived from indole, especially a therapeutically useful compound, characterized in that it is selected from compounds of formula (I) in which R1 represents a halogen or a trifluoromethyl group, R2 represents a hydrogen atom or a C1-C4 alkyl group, R3 represents an isopropyl (1-methylethyl) group or a tert-butyl (1,1-dimethylethyl) group and n=3 or 4 and pharmaceutically acceptable salts of said compounds of formula (I). Application: Treatment of neurodegenerative diseases and more particularly of Parkinson's disease.
Public/Granted literature
- US20110178150A1 Use of Indole Derivatives as NURR-1 Activators for Treating Parkinson's Disease Public/Granted day:2011-07-21
Information query
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