Invention Grant
US08575282B2 Compound modified by a phosphoramidate and/or phosphonamide group and use thereof
有权
由氨基磷酸酯和/或膦酰胺基团修饰的化合物及其用途
- Patent Title: Compound modified by a phosphoramidate and/or phosphonamide group and use thereof
- Patent Title (中): 由氨基磷酸酯和/或膦酰胺基团修饰的化合物及其用途
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Application No.: US13255864Application Date: 2010-03-09
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Publication No.: US08575282B2Publication Date: 2013-11-05
- Inventor: Christian Hackenberger , Giuseppe Del Signore , Remigiusz Serwa , Ina Wilkening , Robert Vallee
- Applicant: Christian Hackenberger , Giuseppe Del Signore , Remigiusz Serwa , Ina Wilkening , Robert Vallee
- Applicant Address: DE Berlin
- Assignee: Freie Universitaet Berlin
- Current Assignee: Freie Universitaet Berlin
- Current Assignee Address: DE Berlin
- Agency: Maschoff Brennan
- Priority: DE102009012640 20090309
- International Application: PCT/EP2010/052968 WO 20100309
- International Announcement: WO2010/102997 WO 20100916
- Main IPC: C08G79/02
- IPC: C08G79/02
Abstract:
A modified compound that has at least one further functional group, in particular a bio- or macromolecule, comprising at least one x-fold (x≧1) chemoselectively incorporated phosphoramidate group of general formula (I), NPO(OR1)(OR1′), and/or at least one x-fold (x≧1) chemoselectively incorporated phosphonamide group of general formula (Ia), NPO(R1)(OR1′). R1 and R1′ is selected from the group containing glycerol, polyglycerol, PEG polymers of the general empirical formula C2nH4n+2On+1 with n≧1, Cn-alkyl chains with n≧1; functionalized Cn-alkyl chains with n≧1, aryls, heteroaryl, silyl, lipids, fluorophores, saccharides, peptides, crown ethers, or a linker, which links the aforementioned groups. R1 and R1′ can be identical to or different from one another.
Public/Granted literature
- US20120065344A1 COMPOUND MODIFIED BY A PHOSPHORAMIDATE AND/OR PHOSPHONAMIDE GROUP AND USE THEREOF Public/Granted day:2012-03-15
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