Invention Grant
US08575319B2 Cleavable vaccine compositions and uses thereof and methods of making and using the same 有权
可切割疫苗组合物及其用途及其制备和使用方法

Cleavable vaccine compositions and uses thereof and methods of making and using the same
Abstract:
The invention relates to methods for making vaccines using linkages that are cleavable under lysosomal processing conditions, and vaccine compositions obtained therefrom. In some embodiments, the vaccines comprise a tumor antigen, an immunogenic carrier and a linker covalently linking the tumor antigen and the immunogenic carrier by a thio ether linkage. Vaccines of preferred embodiments can be used against a cellular proliferative disease that is characterized by the tumor antigen.
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