Invention Grant
- Patent Title: Cleavable vaccine compositions and uses thereof and methods of making and using the same
- Patent Title (中): 可切割疫苗组合物及其用途及其制备和使用方法
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Application No.: US12281229Application Date: 2007-03-09
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Publication No.: US08575319B2Publication Date: 2013-11-05
- Inventor: John M. Timmerman
- Applicant: John M. Timmerman
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Smith, Gambrell & Russell, LLP
- Agent Suzannah K. Sundby, Esq.
- International Application: PCT/US2007/006210 WO 20070309
- International Announcement: WO2007/106435 WO 20070920
- Main IPC: C07K16/00
- IPC: C07K16/00

Abstract:
The invention relates to methods for making vaccines using linkages that are cleavable under lysosomal processing conditions, and vaccine compositions obtained therefrom. In some embodiments, the vaccines comprise a tumor antigen, an immunogenic carrier and a linker covalently linking the tumor antigen and the immunogenic carrier by a thio ether linkage. Vaccines of preferred embodiments can be used against a cellular proliferative disease that is characterized by the tumor antigen.
Public/Granted literature
- US20090017060A1 Cleavable Vaccine Compositions and Uses Thereof and Methods of Making and Using the Same Public/Granted day:2009-01-15
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