Invention Grant
- Patent Title: Method for early diagnosis of carcinomas of the anogenital tract
- Patent Title (中): 早期诊断肛门生殖器癌的方法
-
Application No.: US13496812Application Date: 2010-09-17
-
Publication No.: US08575326B2Publication Date: 2013-11-05
- Inventor: Matthias Dürst , Alfred Hansel , Daniel Steinbach
- Applicant: Matthias Dürst , Alfred Hansel , Daniel Steinbach
- Applicant Address: DE Jena
- Assignee: Oncgnostics GmbH
- Current Assignee: Oncgnostics GmbH
- Current Assignee Address: DE Jena
- Agency: Leason Ellis LLP.
- Priority: EP09011941 20090918
- International Application: PCT/EP2010/005735 WO 20100917
- International Announcement: WO2011/032721 WO 20110324
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12Q1/68 ; C12P19/34

Abstract:
A method for the early diagnosis of carcinomas of the anogenital tract, preferably of the cervical carcinoma, and the preliminary stages thereof is described. The method is based on the determination of the methylation status of segments of the gene regions of ASTN1 (astrotactin 1) and ZNF671 (zinc finger protein 671, transcription factor). A DNA methylation in the promoter region or the 5′-region of these genes is indicative for carcinomas of the anogenital tract or severe preliminary stages thereof. The present invention also relates to kits which permit the conduction of the diagnostic method according to the invention.
Public/Granted literature
- US20120208180A1 METHOD FOR EARLY DIAGNOSIS OF CARCINOMAS OF THE ANOGENITAL TRACT Public/Granted day:2012-08-16
Information query