Invention Grant
- Patent Title: Purine derivatives and their pharmaceutical uses
- Patent Title (中): 嘌呤衍生物及其药物用途
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Application No.: US13578008Application Date: 2011-02-08
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Publication No.: US08575340B2Publication Date: 2013-11-05
- Inventor: Helene Bazin-Lee , Diane Mary Coe , David A. Johnson , Charlotte Jane Mitchell
- Applicant: Helene Bazin-Lee , Diane Mary Coe , David A. Johnson , Charlotte Jane Mitchell
- Applicant Address: US PA Philadelphia
- Assignee: GlaxoSmithKline LLC
- Current Assignee: GlaxoSmithKline LLC
- Current Assignee Address: US PA Philadelphia
- Agent Kathryn L. Coulter
- International Application: PCT/EP2011/051828 WO 20110208
- International Announcement: WO2011/098451 WO 20110818
- Main IPC: A61K31/52
- IPC: A61K31/52 ; C07D473/18 ; A61P31/00 ; A61P35/00 ; A61P37/08 ; A61P29/00 ; A61P37/04 ; A61P11/06
Abstract:
The present invention relates to compounds of formula (I): wherein; R1 represents hydrogen or C1-3alkyl; n is an integer having a value of 1 to 5; X represents O or NH; Y represents C or N; or a pharmaceutically acceptable salt thereof, have been shown to be inducers of human interferon and may possess an improved profile with respect to known inducers of human interferon, for example enhanced potency. The compounds of the invention may therefore be useful in the treatment of various disorders, in particular the treatment of infectious diseases, cancer, allergic diseases and other inflammatory conditions, and their use as vaccine adjuvants.
Public/Granted literature
- US20120315291A1 PURINE DERIVATIVES AND THEIR PHARMACEUTICAL USES Public/Granted day:2012-12-13
Information query
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