Invention Grant
US08575375B2 Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties
有权
具有强效变构GABA受体氯离子载体调节性质的雄甾烷和孕甾类固醇
- Patent Title: Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties
- Patent Title (中): 具有强效变构GABA受体氯离子载体调节性质的雄甾烷和孕甾类固醇
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Application No.: US12664470Application Date: 2008-06-16
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Publication No.: US08575375B2Publication Date: 2013-11-05
- Inventor: Scott P. Runyon , Michael A. Rogawski , Edgar Cook , John Kepler , Hernan Navarro , Rafal Kaminski , Matthew Orr
- Applicant: Scott P. Runyon , Michael A. Rogawski , John Kepler , Hernan Navarro , Rafal Kaminski , Matthew Orr , Kevin M. Cook
- Applicant Address: US NC Research Triangle Park US DC Washington
- Assignee: Research Triangle Institute,The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: Research Triangle Institute,The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US NC Research Triangle Park US DC Washington
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- International Application: PCT/US2008/067059 WO 20080616
- International Announcement: WO2008/157460 WO 20081224
- Main IPC: C07J41/00
- IPC: C07J41/00
Abstract:
This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
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