Invention Grant
- Patent Title: Preparation of alpha-hydroxyketones
- Patent Title (中): α-羟基酮的制备
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Application No.: US13557281Application Date: 2012-07-25
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Publication No.: US08575394B2Publication Date: 2013-11-05
- Inventor: Nicole End , Reinhard H. Sommerlade , Yvonne Richter
- Applicant: Nicole End , Reinhard H. Sommerlade , Yvonne Richter
- Applicant Address: DE Ludwigshafen
- Assignee: BASF SE
- Current Assignee: BASF SE
- Current Assignee Address: DE Ludwigshafen
- Agency: Shruti Costales
- Priority: EP04103236 20040708
- Main IPC: C07C225/00
- IPC: C07C225/00 ; C07C223/00

Abstract:
A process for the preparation of an 1,1-disubstituted oxirane is disclosed, wherein an organic sulphide is reacted in a polar solvent with an educt containing a leaving group attached to a primary or secondary carbon atom, and/or the sulfonium salt formed in this way is reacted with a ketone in presence of a base and a polar solvent. Oxiranes of the type obtained may be further converted into the corresponding α-hydroxyketone or α-aminoketone, either in one step by subjecting to aerobic oxidation in the presence of a transition metal catalyst, or in two steps by hydrolyzation in the presence of an aqueous acid to the corresponding dialcohol and subsequent selective oxidation. Further described are some novel epoxide intermediates. The α-hydroxyketones and α-aminoketones thus obtainable are useful inter alia as photoinitiators.
Public/Granted literature
- US20120289721A1 PREPARATION OF ALPHA-HYDROXYKETONES Public/Granted day:2012-11-15
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