A serial surge suppression and overload protection optimization device has an input terminal, an output terminal and multiple surge suppression units. The surge suppression units are serially connected between the input terminal and the output terminal. Each surge suppression unit has two parallel inductors and multiple surge absorbing elements. Each surge absorbing element is connected to an output end of one of the parallel inductors and has a fuse serially connected therewith. When surge energy is excessively large, the fuse melts to separate the surge absorbing element from a main power loop without causing a short circuit within the main power loop due to the meltdown of the fuse. The optimization device is used with an automatic overload protection unit to normally supply power to equipment connected to the output terminal thereof and ensure electrical safety protection with a bypass circuit design thereof.