A PAM-N decision feedback equalizer (DFE) comprises a coefficient computation unit; a feedback unit that mitigates, using computed feedback coefficients, effects of interference from data symbols; an error-and-decision unit for at least computing a least error value respective to one of a plurality of decision levels, wherein the least error value indicates a difference of a pseudo equalized input PAM-N data symbol from an optimal position of the one of the plurality of decision levels, wherein the one of the plurality of decision levels corresponds to a modulation level used to modulate data in the input PAM-N data symbol; and a calibration unit for adaptively setting the plurality of decision levels based, in part, on the least error value, thereby enabling for compensating for gain changes resulted by a cable on which the input PAM-N data symbol is received and further compensating for embedded offsets of the error-and-decision unit.