Digital predistorter circuits with selectable basis function configurations are described. In some embodiments, an input scaling block is introduced prior to a basis function generator structure. The input scaling factor is based on the input signal's average power. In other embodiments, configurable connection coefficients are used to construct the orthogonal basis functions. Multiple sets of tap weights for the predistorter are maintained, each set corresponding to a given basis function configuration. In an example method for pre-distorting an input signal to compensate for distortion introduced by an electronic device, a statistic characterizing the input signal is calculated, and one of a pre-determined set of basis function configurations is selected, based on the statistic. A set of pre-distortion model weights corresponding to the selected basis function configuration are determined, after which the selected basis function configuration and the corresponding set of pre-distortion model weights are applied to the input signal.