A computer-implemented method of imaging an assay sample having a set of individual samples using a camera is provided. A set of image frames is received. The set of image frames corresponds to an image stream of the assay obtained by the camera. A set of measurement results is identified. Individual measurement results in the set of measurement results are respectively associated with individual image frames in the set of image frames. A subset of measurement results is selected based, at least in part, on an exposure time. Individual measurement results in the subset of measurement results are combined to obtain an integrated measurement result.