Write-through-read (WTR) comparator circuits and related WTR processes and memory systems are disclosed. The WTR comparator circuits can be configured to perform WTR functions for a multiple port file having one or more read and write ports. One or more WTR comparators in the WTR comparator circuit are configured to compare a read index into a file with a write index corresponding to a write-back stage selected write port among a plurality of write ports that can write data to the entry in the file. The WTR comparators then generate a WTR comparator output indicating whether the write index matches the read index to control a WTR function. In this manner, the WTR comparator circuit can employ less WTR comparators than the number of read and write port combinations. Providing less WTR comparators can reduce power consumption, cost, and area required on a semiconductor die for the WTR comparator circuit.