An adjustable pressure cuff device is provided for the arm or leg of a user for stimulating blood flow and preventing blood clots. The pressure cuff contains a number of bladders which wrap in the direction of the cuff and which are arranged in succession down the arm or leg of a user. An air compressor is connected to the bladders via a multiplicity of tubes, each of which contain a valve. A control module runs the air compressor and sequentially opens the valves to provide air pressure to the bladders in succession along the arm or leg of a user. Further, between the bladders and the valves, additional tubes containing valves are provided to equalize pressure between bladders before exhausting the air from a previously pressurized bladder to save power and allow for increased patterns of bladder pressure. The pressure levels and bladder dwell times may be adjusted by the user or based on predetermined settings. Optionally, the device provides electrical stimulation, pulsations, heating, and cooling.