A reusable item shipping container comprises a housing that is configured to retain an item therein and has an opening for inserting or removing the item therefrom. First and second sealing flaps are disposed on the housing adjacent the opening. In a first configuration, the first sealing flap is configured to be folded into the housing or across the opening and the second sealing flap is configured to be folded over the opening to seal the housing. In a second configuration, the first sealing flap is configured to be folded across the opening and to seal the housing after the second folding flap has sealed the opening and the item shipping container has been opened.