Invention Grant
- Patent Title: High throughput nucleic acid sequencing by spacing
- Patent Title (中): 通过间隔进行高通量核酸测序
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Application No.: US12738884Application Date: 2008-10-23
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Publication No.: US08592182B2Publication Date: 2013-11-26
- Inventor: Mark Stamatios Kokoris , Robert N. McRuer
- Applicant: Mark Stamatios Kokoris , Robert N. McRuer
- Applicant Address: US WA Seattle
- Assignee: Stratos Genomics Inc.
- Current Assignee: Stratos Genomics Inc.
- Current Assignee Address: US WA Seattle
- Agency: Seed IP Law Group PLLC
- International Application: PCT/US2008/081025 WO 20081023
- International Announcement: WO2009/055617 WO 20090430
- Main IPC: C12P19/34
- IPC: C12P19/34 ; C12Q1/68 ; C07H21/00 ; C07H21/04

Abstract:
Nucleic acid sequencing methods and related devices, products and kits are disclosed. Methods for sequencing a target nucleic acid comprise providing a daughter strand produced by a template-directed synthesis, the daughter strand comprising a plurality of subunits coupled in a sequence corresponding to a contiguous nucleotide sequence of all or a portion of the target nucleic acid, wherein the individual subunits comprise a probe and a reporter construct. The subunit encodes sequence information in its reporter construct that is less than sequence information in the corresponding portion of the target nucleic acid. The reduced information allows for reduced resolution requirements on the detection system and for increased size of resolvable reporter groups.
Public/Granted literature
- US20100297644A1 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY SPACING Public/Granted day:2010-11-25
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